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KMID : 0366919920040010001
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Sungkyun Pharmceutical Journal
1992 Volume.4 No. 1 p.1 ~ p.10
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Sesquiterpene Lactone
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Abstract
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Sesquiterpene lactones have been increasingly reported during the last decade due to their various biological and pharmacological activities, especially cytotoxic and antitumor properties. The activities come generally form the reaction of
sesquiterpene
lactone with the sulfhydryl (SH) group of biologically essential proteins, such as enzymes. Sesquiterpene lactones can be classified into about 20 skeletal types, but the majority of sesquiterpene lactorne belongs to four categories;
germacranolide,
guainaolide, eudesmanolide and pseudoguaianolide. Here, there four skeletal types of sesquiterpene lactones are reviewed and exemplified respectively. Biological and phamacological properties, and spectroscopic indentificantion of sesquiterpene
lactones
are also discussed.
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KEYWORD
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